Transfrontier Cooperation in the North-west of Russia: 21st century

This study is based on the results of the Transfrontier Cooperation Donor Forum held in St. Petersburg on April 25, 2003 under the EastWest Institute's Regional and Transfrontier Cooperation (RTFC) Program. It contains an overview of transfrontier cooperation in the North-Western Federal District of the Russian Federation and Project Ideas Catalogue. The overview covers the legal framework for TFC, brief TFC-related information on the selected regions, TFC instruments available in the North-West of Russia, donors supporting TFC in the area and transfrontier cooperation in the border regions of Russia's North-West. Additionally, Tacis Cross-Border Small and Micro Project Facilities (the largest and most developed transfrontier cooperation programmes in the North-West of Russia) are examined in more detail. The overview is complemented by the Project Ideas Catalogue (an assessment of transfrontier cooperation needs as understood by local actors)

Survey: Local Consumer Sentiment is Stabilizing

In this paper a mathematical model describing small oscillations of a heterogeneous medium is considered. The medium consists of a partially perforated elastic material and a slightly viscous compressible fluid filling the pores. For the given model the corresponding homogenized problem is constructed by using the two-scale convergence method. The boundary conditions connecting equations of the homogenized model on the boundary between the continuous elastic material and the porous elastic material with fluid are foun

Эффекты ниацин-оксиэтилидендифософнат германата и альфа-липоевой кислоты на диабет-индуцированный оксидантный стресс в ткани сетчатки

Odessa National Medical University, Odessa, Ukraine, Conferinţa știinţifică cu participare internaţională ”Actualităţi în farmacologie și în farmacologia clinică” întru comemorarea celor 100 de ani de la nașterea ilustrului savant, profesor universitar, laureat al Premiului de Stat al Republicii Moldova Efim Muhin 29 noiembrie – 1 decembrie 2018 Chișinău, Republica MoldovaEffects of two weeks treatment with niacin-oxyethylidendiphosphonatogermanate (MIGU-4, 2,5; 25,0 mg/kg, i.p.) and alpha-lipoic acid (LA, 5,0 and 50,0 mg/kg, i.p.) as well as their combined usage (MIGU-4 – 2,5, and LA – 5,0 mg/kg) upon antioxidative enzymes and level of malon dialdehyde (MDA) in retina tissue of rats with streptozotocin (STZ)induced diabetes was determined. It was established that in six weeks after STZ administration superoxiddismutase (SOD) activity decreased by 33,4% (P<0,05), catalase (CAT) – by 28,2% (P<0,05), glutathione peroxidase (GPx) – by 39,8%, glutathione reductase (GR) – by 48,3%, and MDA level raised by 2,65 times when compared with intact rats (P<0,05). MIGU-4 treatment (25,0 mg/kg, i.p.) increased SOD activity by 38,1% (P<0,05), GPx and GR – by 62,9% (P<0,05) and by 35,2% (P<0,05), when compared with diabetes rats. MDA level was reduced by 30,2% (P<0,05) correspondently. The SOD activity under condition of combined MIGU-4 (2,5 mg/ kg) and LA (5,0 mg/kg) administration exceeded its level in rats with diabetes by 41,3% (P<0,05), while activity of GPx and GR also was higher by 52,4% and by 47,8% (P<0,05) correspondently. MDA level reduction was higher than in groups which were given MIGU-4 or LA alone (P<0,05). Thus, niacin-oxyethylidendiphosphonato-germanate caused prevention on diabetes-induced deterioration of antioxidant enzymes activity and level of MDA in retina tissue. Combined usage of MIGU-4 and LA was resulted in heightened preventive effects upon manifestations of oxidative stress.Au fost investigate efectele administrării de două săptămani a hidroxietilidendifosfonat germanatului (MIGU-4, 2,5; 25,0 mg/kg, i.p.) şi a acidului alfa-lipoic (LC, 5,0 şi 50,0 mg/kg, i.p.) şi efectul utilizării lor combinate (MIGU-4 – 2,5 şi LC – 5,0 mg/kg) asupra activităţii enzimelor antioxidante şi nivelului de malondialdehidă (MDA) in ţesutul retinei şobolanilor cu diabet indus de streptozotocină (STZ). S-a constatat că după 6 săptămani de la momentul aplicării STZ, activitatea superoxid dismutazei (SOD) a scăzut cu 33,4% (P <0,05), a catalazei (CAT) – cu 28,2% (P <0,05), a glutationperoxidazei – cu 39,8%, a glutationreductazei (GR) – cu 48,3%, cu o creştere a conţinutului de MDA de 2,65 ori, comparativ cu şobolanii intacţi (P <0,05). Odată cu introducerea MIGU-4 (25,0 mg/kg, i.p.), activitatea SOD a fost mai mare cu 38,1% (P <0,05), a HP şi GR – cu 62,9% (P <0,05 ) şi, respectiv, 35,2% (P <0,05), in comparaţie cu animalele cu diabet zaharat. Nivelul MDA a scăzut cu 30,2% (P <0,05). Eficacitatea MIGU-4 (25,0 mg/ kg) a fost comparabilă cu cea a LK utilizată in doză de 50,0 mg/kg. In cazul folosirii combinate a MIGU-4 (2,5 mg/kg) şi a LC (5,0 mg/kg), activitatea SOD a depăşit-o pe cea a şobolanilor cu diabet zaharat cu 41,3% (P <0,05), GP şi GR fiind mai mari cu 52,4% şi, respectiv, cu 47,8% (P <0,05). Scăderea nivelului MDA a fost mai mare decat in cazul grupurilor care utilizează MIGU-4 sau LC (P <0,05). Astfel, administrarea hidroxietildidenfosfonat germanatului previne dereglările activităţii enzimelor antioxidante şi nivelului MDA induse de diabet in ţesutul retinian. Administrarea asociată a MIGU-4 şi a LC este insoţită de o acţiune preventivă sporită impotriva manifestărilor stresului oxidativ.Исследовали влияние двухнедельного введения ниациноксиэтилидендифосфонат германата (МИГУ-4, 2,5; 25,0 мг/кг, в/бр) и альфа-липоевой кислоты (ЛК, 5,0 и 50,0 мг/кг, в/бр), а также влияние их совместного применения (МИГУ-4 – 2,5, и ЛК – 5,0 мг/кг) на активность антиоксидантних ферментов и уровень малонового диальдегида (МДА) в ткани сетчатки крыс со стрептозотоцин (СТЗ)-индуцированным диабетом. Установлено, что через 6 недель с момента применения СТЗ активность супероксидисмутазы (СОД) уменьшилась на 33,4% (P<0,05), каталазы (КАТ) – на 28,2% (P<0,05), глутатионпероксидазы (ГП) – на 39,8%, глутатионредуктазы (ГР) – на 48,3% при увеличении содержания МДА в 2,65 раза в сравнении с интактными крысами (P<0,05). На фоне введения МИГУ-4 (25,0 мг/кг, в/бр) активность СОД была выше на 38,1% (P<0,05), ГП и ГР – на 62,9% (P<0,05) и соответственно 35,2% (P<0,05) при сравнении с животными с диабетом. При этом уровень МДА уменьшался на 30,2% (P<0,05). При комбинированном применении МИГУ-4 (2,5 мг/кг) и ЛК (5,0 мг/кг) активность СОД превышала таковую у крыс с диабетом на 41,3% (P<0,05), в то время как активность ГП и ГР была выше на 52,4% и соответственно 47,8% (P<0,05) соответственно. Величина снижения уровня МДА была выше, чем в группах с применением одного МИГУ-4 или ЛК (P<0,05). Таким образом, применение ниацин-оксиэтилидендифосфонат германата предотвращает диабет-вызванные нарушения активности антиоксидантных ферментов и уровня МДА в ткани сетчатки. Совместное введение МИГУ-4 и ЛК сопровождается потенцированным превентивным действием в отношении проявлений оксидативного стресса

колективна монографія

Кримінальний процесуальний кодекс 2012 року: ідеологія та практика правозастосування: колективна монографія / за заг. ред. Ю. П. Аленіна ; відпов. за вип. І. В. Гловюк. - Одеса : Видавничий дім «Гельветика», 2018. - 1148 с

Elevated NSD3 histone methylation activity drives squamous cell lung cancer

Amplification of chromosomal region 8p11-12 is a common genetic alteration that has been implicated in the aetiology of lung squamous cell carcinoma (LUSC)(1-3). The FGFR1 gene is the main candidate driver of tumorigenesis within this region(4). However, clinical trials evaluating FGFR1 inhibition as a targeted therapy have been unsuccessful(5). Here we identify the histone H3 lysine 36 (H3K36) methyltransferase NSD3, the gene for which is located in the 8p11-12 amplicon, as a key regulator of LUSC tumorigenesis. In contrast to other 8p11-12 candidate LUSC drivers, increased expression of NSD3 correlated strongly with its gene amplification. Ablation of NSD3, but not of FGFR1, attenuated tumour growth and extended survival in a mouse model of LUSC. We identify an LUSC-associated variant NSD3(T1232A) that shows increased catalytic activity for dimethylation of H3K36 (H3K36me2) in vitro and in vivo. Structural dynamic analyses revealed that the T1232A substitution elicited localized mobility changes throughout the catalytic domain of NSD3 to relieve auto-inhibition and to increase accessibility of the H3 substrate. Expression of NSD3(T1232A) in vivo accelerated tumorigenesis and decreased overall survival in mouse models of LUSC. Pathological generation of H3K36me2 by NSD3(T1232A) reprograms the chromatin landscape to promote oncogenic gene expression signatures. Furthermore, NSD3, in a manner dependent on its catalytic activity, promoted transformation in human tracheobronchial cells and growth of xenografted human LUSC cell lines with amplification of 8p11-12. Depletion of NSD3 in patient-derived xenografts from primary LUSCs containing NSD3 amplification or the NSD3(T1232A)-encoding variant attenuated neoplastic growth in mice. Finally, NSD3-regulated LUSC-derived xenografts were hypersensitive to bromodomain inhibition. Thus, our work identifies NSD3 as a principal 8p11-12 amplicon-associated oncogenic driver in LUSC, and suggests that NSD3-dependency renders LUSC therapeutically vulnerable to bromodomain inhibition

Spectrum of One-dimensional Vibrations of a Layered Medium Consisting of a Kelvin-Voigt Material and a Viscous Incompressible Fluid

The paper considers a mathematical model for natural vibrations of a periodic layered medium. The medium consists of a viscoelastic Kelvin-Voigt material and a viscous incompressible fluid. For the given model, two homogenized models are derived. They correspond to the cases of transverse and longitudinal vibrations of the layered medium. It is shown that the spectrum of each homogenized model is the union of roots of the corresponding quadratic equations.Рассмотрена математическая модель, описывающая собственные колебания периодической слоистой среды, составленной из вязкоупругого материала Кельвина-Фойгта и вязкой несжимаемой жидкости. Для данной модели построены две усредненные модели, соответствующие поперечнымипродольнымколебаниямслоистойсреды. Показано,чтоспектркаждойусредненноймодели есть объединение корней соответствующих квадратных уравнений

DEVELOPMENT OF CLINICAL LEGAL STUDIES AS AN ESSENTIAL COMPONENT IN THE MODERNIZATION OF LEGAL EDUCATION

Introduction: the current modernization of legal education in Russia puts emphasis upon the development of its practical component. Enhancement of the quality of higher legal education directly depends on the inclusion of practice-oriented components. In this respect, it is necessary to develop training of future lawyers based on legal clinics as structural units of higher educational institutions. Clinical legal education should combine the special pre-theoretical training of students as well as the practical work that has to do with rendering free legal assistance to socially vulnerable categories of citizens. Materials and Methods: comparative analysis of the experience of various Russian legal clinics made it possible to identify the similarities and differences between them, comparing different versions of clinical training, recognizing common problems and proposing an effective model of legal clinics’ activity enabling the learners to obtain professional skills and to improve the quality of legal services rendered by students. Results: the authors demonstrate and analyze different activities of Russian legal clinics, established in institutions of higher education. The process of detecting differences among structural divisions of universities providing legal training, allowed us to determine the common problems encountered by a legal clinic during day-to-day activity. The authors propose a model for legal clinics’ effective activity pertaining to the implementation of a practice-based training of students. The article reveals the learning process of developing professional skills (interviewing and advising on legal issues, drafting legal documents, case analysis, etc.) gradually. Necessary conditions for ensuring quality of legal services provided by students under the guidance of teachers are highlighted. Discussion and Conclusions: recommendations for the future development of legal clinic education in Russian universities are given. The importance of expanding legal clinic-based education, its implementation in the educational process is underscored. The significance of legal clinics for bachelor’s and master’s degree programmes is pointed

Усреднение уравнений акустики для частично перфорированного упругого материала со слабовязкой жидкостью

In this paper a mathematical model describing small oscillations of a heterogeneous medium is considered. The medium consists of a partially perforated elastic material and a slightly viscous compressible fluid filling the pores. For the given model the corresponding homogenized problem is constructed by using the two-scale convergence method. The boundary conditions connecting equations of the homogenized model on the boundary between the continuous elastic material and the porous elastic material with fluid are foundРассмотрена математическая модель, описывающая малые колебания гетерогенной среды, состо- ящей из частично перфорированного упругого материала и слабовязкой сжимаемой жидкости, заполняющей поры. Для данной модели с помощью метода двухмасштабной сходимости постро- ена соответствующая усредненная модель и найдены граничные условия, связывающие уравнения усредненной модели на границе между сплошным упругим материалом и пористым упругим материалом с жидкость

Спектр одномерных собственных колебаний двухфазных слоистых композитов

The spectrum of one-dimensional eigenoscillations of two-phase composites with a periodic structure is studied. Their phases are isotropic elastic or viscoelastic materials, and the period consists of 2M alternating plane layers of the first and second phases. Equations whose roots form the spectrum are derived and their asymptotic behaviour is investigated. In particular, it is established that all finite limits of sequences of the spectrum points depend on the volume fractions of the phases and do not depend on the number M and distances between the layers boundaries inside the periodИзучен спектр одномерных собственных колебаний двухфазных композитов с периодической структурой. Их фазами являются изотропные упругие или вязкоупругие материалы, а период состоит из 2M чередующихся плоских слоев первой и второй фаз. Выведены уравнения, корни которых образуют спектр, и исследовано их асимптотическое поведение. В частности, установлено, что все конечные пределы последовательностей точек спектра зависят от объемных долей фаз и не зависят от числа M и расстояний между границами слоев внутри период